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Correspondence
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Volume 356:1888-1889 May 3, 2007 Number 18
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Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis

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by Kuhle, J.
To the Editor: Seven different studies so far have shown controversial correlations (ranging from highly significant to not significant at all) regarding the predictive value of antimyelin antibodies in patients with a clinically isolated syndrome suggestive of multiple sclerosis.1,2,3,4,5 To validate our initial findings1 in other populations with a clinically isolated syndrome, we provided the same antimyelin-antibody immunoblot assay for all these studies. Controversial results may thus reflect differences in study populations and designs, rather than in methods. The article by Kuhle et al. (Jan. 25 issue)3 demonstrates these differences. First, apart from antimyelin antibodies, other factors — such as . . . [Full Text of this Article]



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