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Volume 356:1914 May 10, 2007 Number 19
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Quadrivalent Vaccine against HPV to Prevent High-Grade Cervical Lesions

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Commentary
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 by Charo, R. A.
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 by Agosti, J. M.
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 by Baden, L. R.
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 by Sawaya, G. F.

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 by The FUTURE II Study Group
In this large, randomized, placebo-controlled trial, a quadrivalent vaccine (including human papillomavirus types 6, 11, 16 and 18) given at day 1, month 2, and month 6 was associated with a significant reduction in the occurrence of cervical intraepithelial neoplasia. No beneficial effect was observed on prevalent lesions. The prevention benefit for incident lesions associated with HPV-16 and HPV-18 appears to increase with time.




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