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In 1992, the announcement that pregnancies had been achieved after intracytoplasmic injection of a single sperm into an oocyte sent shock waves through the andrology community. Was the male gamete's role in reproduction now merely to contribute chromosomes? Was there any benefit to the clinical investigation of male infertility? Leaders in the field of andrology, including the editors of and several contributors to The Sperm Cell, argued that intracytoplasmic sperm injection (ICSI) was simply a tool to assist fertilization for men with unexplained or undiagnosed subfertility and would not replace the need to further our understanding of sperm function. Indeed,
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