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Previous Volume 356:185-187 January 11, 2007 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Renal-cell carcinoma is among the most resistant of tumors to therapy. Until 2005, only a single treatment, high-dose interleukin-2, had been approved by the Food and Drug Administration (FDA) for the treatment of this disease. The approval was based on durable complete responses in 5% of patients with metastatic disease,¹ but high-dose therapy with interleukin-2 is quite toxic, and in most patients its benefit is unclear.

In this issue of the Journal, Motzer et al.² and Escudier et al.³ report on the results of phase 3 trials of two oral, small-molecule kinase inhibitors, sunitinib malate and sorafenib, respectively. Both drugs . . . [Full Text of this Article]

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From the Division of Hematology–Oncology and the Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas.

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