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Clinical Implications of Basic Research
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Volume 356:2208-2210 May 24, 2007 Number 21
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A Healthy Tan?
Gregory Barsh, M.D., Ph.D., and Laura D. Attardi, Ph.D.

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For the past 500 million years or so, the tumor suppressor and transcription factor known as p53 has been the guardian of the genome in multicellular organisms. It mediates the response to DNA damage by inducing cell-cycle arrest and facilitating DNA repair or, if the damage is particularly severe, by triggering apoptosis. Both responses are critical to cancer prevention. More recently — about 1 million years ago — a tanning response evolved in our hominid ancestors, in which the accumulation of melanin granules in keratinocytes provides physical protection against the DNA-damaging effects of sunlight. The tanning response to "sunseeking" behavior . . . [Full Text of this Article]


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From the Stanford University School of Medicine, Stanford, CA.



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