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In 1989, two consecutive reports in Science described the cloning of vascular endothelial growth factor (VEGF) (the protein originally identified by Harold Dvorak and colleagues as vascular permeability factor), a landmark in the field of angiogenesis. Subsequent studies and clinical trials have since confirmed that VEGF is the dominant angiogenic factor in numerous diseases. Furthermore, numerous recent clinical trials have shown that the inhibition of VEGF can benefit patients with a variety of diseases in which angiogenesis has a role. Napoleone Ferrara, the editor of Angiogenesis, was an author of one of the 1989 reports in Science; his laboratory not
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