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Correspondence
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Volume 356:2324-2325 May 31, 2007 Number 22
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Coronary Microvascular Dysfunction

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by Camici, P. G.
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To the Editor: Camici and Crea (Feb. 22 issue)1 review the different causes and mechanisms of coronary microvascular dysfunction. However, coronary microvascular dysfunction due to aging deserves further comment. Age is a recognized risk factor for cardiovascular disease, and senescence is associated with morphologic and functional changes in the coronary microvasculature.2 Studies in animals have shown that coronary flow reserve and the endothelium-dependent dilatation of the resistance arteries decrease with age.3 It has been suggested that endothelium-dependent dilatation of the resistance coronary arteries evoked by acetylcholine may decrease with age in humans.4

The mechanisms underlying the age-associated reduction in the . . . [Full Text of this Article]



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