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Volume 356:2421-2422 June 7, 2007 Number 23
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Hepatitis E Vaccine

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 by Shrestha, M. P.
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To the Editor: The study by Shrestha et al. (March 1 issue),1 which evaluated a vaccine for hepatitis E virus (HEV), represents a major advance but continues to raise ethical concerns. The trial of the HEV recombinant protein (rHEV) vaccine, conducted by the U.S. military and GlaxoSmithKline, was forced out of a Nepalese community after protests about whether residents would have access to the vaccine after the trial.2 The study was subsequently relocated to the Nepalese Army. The consent of soldiers may be "unduly influenced . . . by fear of disapproval or retaliation if they refuse,"3 which is why research involving . . . [Full Text of this Article]




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