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Correspondence
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Volume 356:2537-2538 June 14, 2007 Number 24
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Vancomycin-Induced Immune Thrombocytopenia

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 by Von Drygalski, A.
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To the Editor: In the report by Von Drygalski and colleagues on vancomycin-induced immune thrombocytopenia (March 1 issue),1 the positive human platelet factor 4 enzyme-linked immunosorbent assay (PF4 ELISA) was used to rule out the diagnosis of heparin-induced thrombocytopenia. Although this test is highly sensitive, it has been recommended2 that the test not be used alone but be combined with a functional assay, such as a 14C-serotonin release assay, which is the gold standard. Furthermore, the authors report that platelet counts increased after the withdrawal of vancomycin. However, in the patient with vancomycin-induced thrombocytopenia whose platelet counts are shown in . . . [Full Text of this Article]




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