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Editorial
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Volume 356:2641-2643 June 21, 2007 Number 25
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Entecavir Surprise
Martin S. Hirsch, M.D.

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The truly remarkable advances in the treatment of human immunodeficiency virus type 1 (HIV-1) infection have turned a once nearly uniform death sentence into a treatable condition. The survival benefits resulting from the use of antiretroviral drugs are estimated to have saved 3 million years of life; these benefits compare favorably with those of many other interventions for chronic diseases.1 In the 20 years since zidovudine was first approved, more than 20 other antiretroviral drugs have emerged, including inhibitors of HIV-1 reverse transcriptase, protease, and attachment and entry. Several other experimental agents now in expanded-access programs may be approved in . . . [Full Text of this Article]


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From the Department of Medicine, Massachusetts General Hospital, Boston, and the Partners AIDS Research Center, Cambridge, MA.


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