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Previous Volume 356:2704-2712 June 28, 2007 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 51-year-old woman presents with a generalized tonic–clonic seizure. After a brief postictal period, she recovers fully and does not report headache or other neurologic symptoms. She takes no medications and her medical history is unremarkable. Computed tomography of the head suggests a right occipital arteriovenous malformation, without evidence of hemorrhage. Computed tomographic angiography, magnetic resonance imaging, and magnetic resonance angiography of . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Evaluation

            Imaging

            Risk Assessment

            Natural History of Untreated Arteriovenous Malformations

Management

            Surgical Resection

            Radiosurgery

            Embolization

            Management of Aneurysms Associated with Arteriovenous Malformation

            Multidisciplinary Therapy

Areas of Uncertainty

Guidelines from Professional Societies

Summary and Recommendations

Source Information

From the Department of Neurosurgery, Division of Cerebrovascular Surgery, Brigham and Women's Hospital and Harvard Medical School — both in Boston.

Address reprint requests to Dr. Friedlander at the Department of Neurosurgery, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, or at rfriedlander@rics.bwh.harvard.edu.

Related Letters:

Arteriovenous Malformations of the Brain
Horton J. C., Friedlander R. M.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:1774-1775, Oct 25, 2007. Correspondence

This article has been cited by other articles:

• Murphy, P. A., Lam, M. T. Y., Wu, X., Kim, T. N., Vartanian, S. M., Bollen, A. W., Carlson, T. R., Wang, R. A. (2008). Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc. Natl. Acad. Sci. USA 105: 10901-10906 [Abstract] [Full Text]  
• Horton, J. C., Friedlander, R. M. (2007). Arteriovenous Malformations of the Brain. NEJM 357: 1774-1775 [Full Text]