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Previous Volume 356:2732-2733 June 28, 2007 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the fall of 2005, GlaxoSmithKline called attention to recently collected safety data indicating an increased risk of major congenital malformations among infants exposed during organogenesis to GlaxoSmithKline's selective serotonin reuptake inhibitor (SSRI), paroxetine. Among 527 fetuses exposed to paroxetine in the first trimester, 23 were born with major congenital malformations. Most of the malformations were cardiovascular, and the majority of those were ventricular septal defects. As compared with infants born to women taking any other antidepressant agent during the first trimester, the adjusted odds ratio for any malformation was 2.2 (95% confidence interval [CI], 1.3 to 3.6). Previously published . . . [Full Text of this Article]

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From the Division of Maternal–Fetal Medicine, Massachusetts General Hospital, Boston.

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