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Correspondence
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Volume 356:2744-2745 June 28, 2007 Number 26
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Bronchial Thermoplasty

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by Solway, J.
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by Cox, G.
To the Editor: The article by Cox et al. (March 29 issue)1 about bronchial thermoplasty as a treatment for asthma, as well as the accompanying editorial by Solway and Irvin,2 point up the crucial role played by airway smooth muscle in the pathophysiology of this disease. The common assumption is that airway inflammation, usually allergic in origin, is the primary event in asthma, and that smooth-muscle hyperplasia, increased contractility of airway smooth muscle, and intermittent airway obstruction are secondary findings. However, it is possible that recurrent episodes of airway smooth-muscle constriction could cause an inflammatory reaction leading to the release . . . [Full Text of this Article]



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