That mammographic density is an important risk factor for breastcancer was first recognized by Wolfe in the 1970s. His pioneeringobservation has since been confirmed in more than 42 studies,the vast majority of which have shown an association betweenincreased mammographic density and the risk of breast cancer.1Women in the highest quartile of mammographic density have arisk of breast cancer that is approximately four to six timesas high as that among women of similar age who are in the lowestquartile. Only two other factors increase the risk of breastcancer more than mammographic density: . . . [Full Text of this Article]
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From the Departments of Medicine and Epidemiology and Biostatistics and the General Internal Medicine Section, Department of Veterans Affairs, University of California, San Francisco, San Francisco.
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