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Volume 356:311-312 January 18, 2007 Number 3
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Reversal of Type 1 Diabetes in Mice

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by Melton, D. A.
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To the Editor: Dr. Melton (July 6 issue)1 misrepresents my study on the reversal of type 1 diabetes in mice and its implications for new treatment strategies in humans.2 As in a previous study,3 my colleagues and I discovered that an immune therapy triggered a permanent reversal of end-stage type 1 diabetes in mice. The treatment involved two components: injecting the mice with an immune adjuvant (to induce the production of tumor necrosis factor, which destroys autoreactive T cells) and injecting splenocytes from a donor mouse.

Dr. Melton writes that we ascribed the reversal of type 1 diabetes in a . . . [Full Text of this Article]



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