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Previous Volume 356:312-313 January 18, 2007 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Strains of influenza A (H3N2) virus with a specific mutation (Ser31Asn) have recently shown a dramatic increase in resistance to amantadine in communities in Asia and North America. This resistance in 70 to 90% of strains has occurred despite the absence of sustained selective drug pressure.^1,2 We conducted a multicenter study to assess the prevalence of such resistance during the 2005–2006 influenza season in Japan. The study included molecular analysis of the hemagglutinin gene of resistant and sensitive influenza A (H3N2) viruses.

We examined a total of 415 isolates of influenza A virus, sampled from November 2005 . . . [Full Text of this Article]

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