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Correspondence
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Volume 356:426-428 January 25, 2007 Number 4
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Antimyelin Antibodies with No Progression to Multiple Sclerosis

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To the Editor: The presence of antibodies against myelin, myelin oligodendrocyte glycoprotein (MOG), and myelin basic protein (MBP) in serum from patients with a clinically isolated syndrome and multiple lesions detected on magnetic resonance imaging (MRI) has been associated with the more rapid development of a second neurologic event and conversion to clinically definite multiple sclerosis. However, there is controversy concerning this issue.1,2,3 Discordant results have not been explained, but clinical or laboratory differences in assay methods have been identified as possible causes. We investigated whether the presence of serum antibodies against MBP and MOG in patients with a clinically . . . [Full Text of this Article]


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