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Previous Volume 356:527-529 February 1, 2007 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the Case Record regarding severe falciparum malaria in a 3-year-old girl (Oct. 19 issue),¹ Fraser et al. discuss the use of exchange transfusion and attribute the patient's clinical improvement to this treatment. Current evidence does not support this conclusion: a meta-analysis of eight comparative trials showed no significant benefit of adjunctive exchange transfusion over chemotherapy alone. Although there was systematic bias toward use of exchange transfusion in patients with severe malaria, subgroup analysis showed no additional benefit at any level of parasitemia.²

Treatment of severe malaria with artesunate, as compared with quinine, has been shown to . . . [Full Text of this Article]

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