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Volume 356:550 February 8, 2007 Number 6
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Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome

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by Guzick, D. S.

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by Legro, R. S.
This multicenter, randomized trial compared the effects of clomiphene citrate plus placebo, metformin plus placebo, and combination therapy in infertile women with the polycystic ovary syndrome. The rate of live birth was significantly higher with clomiphene than with metformin; there was no significant difference between the rates with combination therapy and with clomiphene alone. Multiple birth was a complication associated with clomiphene but was infrequent. These data support the use of clomiphene over metformin for the treatment of infertility in women with the polycystic ovary syndrome.



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