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Previous Volume 356:642-643 February 8, 2007 Number 6 Next

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To the Editor: Prolonged survival in homozygous sickle cell disease is more common than previously thought. A Jamaican study¹ in 1968 described 60 patients who were 30 years of age or older, and the Cooperative Study of Sickle Cell Disease in the United States² estimated a median survival of 42 to 48 years.

The Sickle Cell Clinic at the University of the West Indies has treated 102 patients (64.7% women) who survived beyond their 60th birthday; of these patients, 58 are now dead, 4 have emigrated, and 40 are still alive. The diagnosis of homozygous sickle cell disease was based . . . [Full Text of this Article]

This article has been cited by other articles:

• Higgs, D. R., Wood, W. G. (2008). Genetic complexity in sickle cell disease. Proc. Natl. Acad. Sci. USA 105: 11595-11596 [Full Text]