The treatment of the pain of chronic pancreatitis continuesto be problematic. Although severe calcific pancreatitis canbe asymptomatic, it can cause disabling pain daily. Medicalmanagement with abstinence from alcohol, a low-fat diet, supplementarypancreatic enzymes, and nonnarcotic analgesic agents is thefirst step in therapy but is often ineffective. Pain managementwith the long-term use of narcotics is common but is often unsatisfactorybecause of tolerance to the medication, loss of efficacy, andcomplications of drug dependency. Injections of octreotide areused for pain control, but efficacy studies have been contradictory.Notably, the placebo response rate in patients . . . [Full Text of this Article]
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From the Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor.
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N Engl J Med 2007;
356:2101-2104, May 17, 2007.
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This article has been cited by other articles:
Wong, T., Delhaye, M., Deviere, J., Dumonceau, J.-M., Buscaglia, J. M., Kalloo, A. N., Jagannath, S. B., Siriwardena, A. K., Kleeff, J., Friess, H., Buchler, M. W., Cahen, D. L., Gouma, D. J., Bruno, M. J., Elta, G. H.
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