The sequence of the four nucleotides of the genetic code islike an indelible ink that, with rare exceptions, is faithfullytranscribed from cell to cell and from generation to generation.But on top of this code lies another one, literally "epigenetic,"which is represented by methyl groups added to the DNA basecytosine, as well as covalent changes in histone proteins aroundwhich the DNA is coiled. This epigenetic information is morelike a code written in pencil in the margins around the DNA.Although the genome largely distinguishes one person from another,the epigenome, or epigenetic information, distinguishes . . . [Full Text of this Article]
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From the Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York (R.G.G.); and the Departments of Medicine, Molecular Biology and Genetics, and Oncology, Johns Hopkins University School of Medicine, Baltimore (A.P.F.).
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