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Correspondence
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Volume 356:752-753 February 15, 2007 Number 7
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Gene-Expression–Based Predictors for Breast Cancer

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by Fan, C.
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To the Editor: Fan et al. (Aug. 10 issue)1 compared genetic predictors of breast-cancer recurrence in a retrospective microarray data set that was previously used to discover four of the five predictors — the only exception being the ratio of the levels of expression of homeobox 13 (HOXB13) and interleukin 17B receptor (IL17BR) (the two-gene ratio). They found that the two-gene ratio did not predict recurrence. This finding is contrary to those in peer-reviewed studies,2,3,4,5 including a retrospective review of a prospective cooperative-group trial of adjuvant tamoxifen,3 which showed that the two-gene ratio predicted relapse and death but only in . . . [Full Text of this Article]


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