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FOCUS ON RESEARCH

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Volume 356:771-773 February 22, 2007 Number 8
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DNA Repair and Survival in Lung Cancer — The Two Faces of Janus
Adi F. Gazdar, M.D.

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 by Zheng, Z.

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 by Zheng, Z.
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Lung cancer, the most common cause of cancer deaths globally, results in about 1 million deaths each year. Despite advances in treatment over the past two decades, the improvement in long-term survival has been limited: only about 15% of patients survive for 5 years or longer. The high mortality is due mainly to early and widespread dissemination of the cancer, which means that surgical removal of early-stage non–small-cell lung cancer results in the best chance for long-term survival. Chemotherapy for advanced non–small-cell lung cancer (which accounts for about 85% of all lung cancers) or as adjuvant treatment for patients with . . . [Full Text of this Article]


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Dr. Gazdar is deputy chief of the Hamon Center for Therapeutic Oncology and a professor of pathology at the University of Texas Southwestern Medical Center, Dallas.


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