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Volume 356:774 February 22, 2007 Number 8
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Salmeterol and Fluticasone Propionate and Survival in COPD

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 by Rabe, K. F.

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 by Calverley, P. M.A.
This trial involving more than 6000 patients with chronic obstructive pulmonary disease (COPD) compared the effects on all-cause mortality of treatment with an inhaler containing both salmeterol and fluticasone, salmeterol or fluticasone alone, or placebo. After 3 years, the study showed a reduction of 2.6 percentage points in the mortality rate; this fell short of the study's prespecified goals. There were improved clinical outcomes among patients treated with the combination regimen.




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