In 1949, Ackroyd reported the abrupt onset of severe thrombocytopeniaand purpura in patients receiving the sedative allylisopropylacetylcarbamide(Sedormid).1 All the patients had taken Sedormid previouslyand had become sensitized to it. Today, this classic pictureof drug-induced, immune-mediated thrombocytopenia is most oftencaused by quinine in outpatients and by vancomycin in hospitalizedpatients, as discussed by Von Drygalski et al. in this issueof the Journal (pages 904–910).
In 1973, Rhodes, Dixon, and Silver described thrombocytopeniaand thrombosis occurring a week after the initiation of heparintherapy and provided evidence of an immune pathogenesis forthis complication of heparin . . . [Full Text of this Article]
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Dr. Warkentin is a professor of pathology and molecular medicine and medicine at the Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
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