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Previous Volume 357:64-66 July 5, 2007 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The recently published meta-analysis by Nissen and Wolski,¹ which suggested a significant increase in the risk of myocardial infarction associated with treatment with rosiglitazone (Avandia) and an increase of similar magnitude, albeit nonsignificant, in the risk of death from cardiovascular causes, has created a furor in the press and a quandary for physicians and their patients. Given the vagaries of meta-analyses in general and of this meta-analysis in particular — owing to the absence of primary or time-to-event data, as acknowledged both in the article and in the accompanying editorial² — clinicians have been left uncertain as to whether rosiglitazone . . . [Full Text of this Article]

Source Information

From the Diabetes Center at Massachusetts General Hospital, and Harvard Medical School, Boston.

This article (10.1056/NEJMe078117) was published at www.nejm.org on June 5, 2007.

This article has been cited by other articles:

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• Hoffman, J. M., Shah, N. D., Vermeulen, L. C., Doloresco, F., Grim, P., Hunkler, R. J., Hontz, K. M., Schumock, G. T. (2008). Projecting future drug expenditures--2008. Am J Health Syst Pharm 65: 234-253 [Abstract] [Full Text]  
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• Diamond, G. A., Bax, L., Kaul, S. (2007). Uncertain Effects of Rosiglitazone on the Risk for Myocardial Infarction and Cardiovascular Death. ANN INTERN MED 147: 578-581 [Abstract] [Full Text]  
• Drazen, J. M., Morrissey, S., Curfman, G. D. (2007). Rosiglitazone -- Continued Uncertainty about Safety. NEJM 357: 63-64 [Full Text]