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Previous Volume 357:77-78 July 5, 2007 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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For the past three decades, researchers have been studying the interactions between hematopoietic stem cells and the surrounding cells of the bone marrow. The area where these interactions occur is called the hematopoietic microenvironment.¹ Such interactions are key to the maintenance of hematopoietic stem cells and do not occur randomly in the bone marrow cavity; instead, they are preferentially located in different places within this space — hence the phrase "stem-cell niche."² A stem-cell niche is an accumulation of hematopoietic stem cells in a particular place that sustains the survival and function of the cells through cell–cell and cell–matrix interactions. . . . [Full Text of this Article]

Source Information

From the Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati.

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