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Volume 357:88-90 July 5, 2007 Number 1
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Varicella–Zoster Vaccine

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 by Kimberlin, D. W.
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To the Editor: In their article about the varicella–zoster virus (VZV) vaccine for the prevention of herpes zoster, Kimberlin and Whitley (March 29 issue)1 mention that the frequency and type of serious adverse events were similar for the vaccinees and placebo recipients. However, in the Adverse Event Monitoring Substudy, which involved a closely followed subgroup of 3345 recipients of the VZV vaccine (Zostavax, Merck) and 3271 placebo recipients, the rate of serious adverse events was higher among the vaccine recipients than among the placebo recipients (1.9% vs. 1.3%; relative risk, 1.53; 95% confidence interval, 1.04 to 2.25).2 To assess further . . . [Full Text of this Article]




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