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Previous Volume 357:1113-1120 September 13, 2007 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.

A 55-year-old man who is 178 cm tall and weighs 95 kg is hospitalized with community-acquired pneumonia and progressively severe dyspnea. His arterial oxygen saturation while breathing 100% oxygen through a face mask is 76%; a chest radiograph shows . . . [Full Text of this Article]

The Clinical Problem

Pathophysiological Characteristics and Effect of Therapy

Clinical Evidence

Clinical Use

Adverse Effects

Areas of Uncertainty

Guidelines

Recommendations

Source Information

From the Pulmonary and Critical Care and Sleep Medicine Divisions, Brigham and Women's Hospital and Harvard Medical School — both in Boston.

Address reprint requests to Dr. Malhotra at Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, or at amalhotra1@partners.org.

Related Letters:

Low-Tidal-Volume Ventilation
Chiche L., Forel J.-M., Papazian L., Asakura Y., Komatsu T., Busch T., Bercker S., Kaisers U., Malhotra A.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:2518-2520, Dec 13, 2007. Correspondence

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• Malhotra, A, Hillman, D (2008). Obesity and the lung: 3 {middle dot} Obesity, respiration and intensive care. Thorax 63: 925-931 [Abstract] [Full Text]  
• Lytle, F. T., Brown, D. R. (2008). Appropriate Ventilatory Settings for Thoracic Surgery: Intraoperative and Postoperative. SEMIN CARDIOTHORAC VASC ANESTH 12: 97-108 [Abstract]  
• Chiche, L., Forel, J.-M., Papazian, L., Asakura, Y., Komatsu, T., Busch, T., Bercker, S., Kaisers, U., Malhotra, A. (2007). Low-Tidal-Volume Ventilation. NEJM 357: 2518-2520 [Full Text]