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Previous Volume 357:1263-1264 September 20, 2007 Number 12 Next

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To the Editor: Iodine-deficiency disorders are prevalent in regions with low iodine levels but have generally been eliminated in affluent countries through the widespread use of iodized salt.^1,2,3,4 We report on two women, both lifelong residents of the United States, in whom iodine-deficiency disorders developed.

Patient 1 presented with goiter and symptoms of hypothyroidism. Examination of the neck confirmed a diffusely enlarged thyroid gland (approximately 50 g); hypothyroidism was confirmed biochemically (Table 1). A radioactive iodine study, performed before her referral for endocrine evaluation, was reportedly "consistent with hyperthyroidism." The latter finding, together with a history of avoidance . . . [Full Text of this Article]

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