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A 75-year-old woman with more than a 10-year history of hypertension and diabetes mellitus reported a 3-day history of throat discomfort and white eruptions on the tongue. On examination, multiple well-defined, white papules, 2 to 3 mm in diameter with a central punctum, were found on the surface of her tongue (Panel A). She reported only minimal oral pain. A shave biopsy revealed histologic findings typical of herpetic infection, including perinuclear halo, margination of chromatin, and multinucleated cells (Panel B, arrows). Culture of the lesions showed herpes simplex virus type 1 (HSV-1). Differing from herpetic vesicles on the skin, round, . . . [Full Text of this Article] |
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