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Volume 357:1350 September 27, 2007 Number 13
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Mevalonic Aciduria Cured by Bone Marrow Transplantation

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by Neven, B.
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To the Editor: Neven et al. (June 28 issue)1 discuss the use of bone marrow transplantation in the treatment of severe mevalonic aciduria. We provide additional evidence for the effective cure of mevalonic aciduria by hematopoietic stem-cell transplantation.

In February 2006, we performed hematopoietic stem-cell transplantation in an 8-year-old boy who had mevalonic aciduria associated with a polymorphism in the TNFRSF1A gene, using allogeneic bone marrow from a matched sibling. Details of the clinical features of the case and biochemical and genetic evidence for the diagnosis of the periodic fever syndrome have been reported previously.2 The patient's severe febrile episodes, . . . [Full Text of this Article]



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