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Previous Volume 357:1422-1430 October 4, 2007 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Lyme disease, the most common tick-borne infection in the northern hemisphere, is a serious public health problem. In North America, it is caused exclusively by Borrelia burgdorferi sensu stricto (hereafter referred to as B. burgdorferi), whereas in Europe it is caused by B. afzelii, B. garinii, B. burgdorferi, and occasionally by other species of borrelia.¹

This complex infection has a number of objective manifestations, including a characteristic skin lesion called erythema migrans (the most common presentation of early Lyme disease), certain neurologic and cardiac manifestations, and pauciarticular arthritis (the most common presentation of late Lyme disease), all of which . . . [Full Text of this Article]

Chronic Lyme Disease

Categories of Chronic Lyme Disease

Treatment of Post–Lyme Disease Symptoms

Persistent B. burgdorferi Infection and Post–Lyme Disease Symptoms

Advice to Clinicians

Chronic Lyme Disease in the Public Domain

Conclusions

Source Information

From the Departments of Family Medicine and Pediatrics, Connecticut Children's Medical Center, Hartford, and University of Connecticut Health Center, Farmington (H.M.F.); Microbiology Laboratory, Division of Vector-Borne Infectious Diseases, Centers for Diseases Control and Prevention, Fort Collins, CO (B.J.B.J.); Lyme Borreliosis Unit, Health Protection Agency Microbiology Laboratory, Southampton General Hospital, Southampton, United Kingdom (S.O.); Departments of Pediatrics and Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT (E.D.S.); Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston (A.C.S.); and the Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla (G.P.W.)

Address reprint requests to Dr. Feder at the Departments of Family Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, or at hfeder@nso2.uchc.edu.

Related Letters:

An Appraisal of "Chronic Lyme Disease"
Mayer L., Merz S., Maloney E. L., Holmes K. D., Volkman D. J., Cameron D. J., Drapkin M. S., Feder H. M. Jr., the Ad Hoc International Lyme Disease Group
Extract | Full Text | PDF  
N Engl J Med 2008; 358:428-431, Jan 24, 2008. Correspondence

This article has been cited by other articles:

• Hurley, R. A., Taber, K. H. (2008). Acute and Chronic Lyme Disease: Controversies for Neuropsychiatry. J. Neuropsychiatry Clin. Neurosi. 20: iv-6 [Full Text]  
• Mayer, L., Merz, S., Maloney, E. L., Holmes, K. D., Volkman, D. J., Cameron, D. J., Drapkin, M. S., Feder, H. M. Jr., the Ad Hoc International Lyme Disease Group, (2008). An Appraisal of "Chronic Lyme Disease". NEJM 358: 428-431 [Full Text]  
• Tonks, A. (2007). Lyme wars. BMJ 335: 910-912 [Full Text]  
• (2007). Is "Chronic Lyme Disease" Real?. Journal Watch Dermatology 2007: 1-1 [Full Text]