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Volume 357:1469-1472 October 11, 2007 Number 15
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Pluripotency Redux — Advances in Stem-Cell Research
John Gearhart, Ph.D., Evanthia E. Pashos, B.Sc., and Megana K. Prasad, B.Sc.

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A cell's ability to give to rise to all the cell types of the embryo and the adult organism is called pluripotency. Pluripotent cells are found within mammalian blastocysts and persist briefly in embryos after implantation. Embryonic stem cells, derived from the inner cell mass of blastocysts, are a renewable source of pluripotent stem cells that are proving valuable in basic science studies and may eventually become a source of cells for safe, effective cell-based therapies. Much embryonic stem-cell research has focused on determining the molecular signature of pluripotency, and a picture is emerging of a complex interaction among transcription . . . [Full Text of this Article]


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Dr. Gearhart is a professor of gynecology and obstetrics, physiology, comparative medicine, and biochemistry and molecular biology and the director of the Stem Cell Biology Program at the Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, where Ms. Pashos and Ms. Prasad are Ph.D. candidates in the Human Genetics and Molecular Biology Program.

An interview with Dr. Douglas Melton, a scientific director of the Harvard Stem Cell Institute and a professor in the Department of Molecular and Cellular Biology at Harvard University, can be heard at www.nejm.org.



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