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Clinical Implications of Basic Research
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Volume 357:1552-1554 October 11, 2007 Number 15
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Periostin and Myocardial Repair, Regeneration, and Recovery
Gerald W. Dorn, II, M.D.

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Early reperfusion therapy for myocardial infarction has transformed the treatment of this disease. The restoration of blood flow to the heart within hours after thrombotic coronary occlusion reduces infarct size, maintains cardiac function, and minimizes the risk of late heart failure and lethal arrhythmias. However, high success rates of coronary reperfusion, coupled with aggressive efforts to shorten the time from the manifestation of symptoms to the restoration of arterial blood flow, have brought us close to the practical limits of acute revascularization therapy for myocardial infarction.

Recent work by Kuhn et al.1 underscores the influence of postinfarction cellular and molecular . . . [Full Text of this Article]


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From the Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati.



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