Early reperfusion therapy for myocardial infarction has transformedthe treatment of this disease. The restoration of blood flowto the heart within hours after thrombotic coronary occlusionreduces infarct size, maintains cardiac function, and minimizesthe risk of late heart failure and lethal arrhythmias. However,high success rates of coronary reperfusion, coupled with aggressiveefforts to shorten the time from the manifestation of symptomsto the restoration of arterial blood flow, have brought us closeto the practical limits of acute revascularization therapy formyocardial infarction.
Recent work by Kuhn et al.1 underscores the influence of postinfarctioncellular and molecular . . . [Full Text of this Article]
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From the Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati.
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