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Correspondence
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Volume 357:1561-1562 October 11, 2007 Number 15
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Hypercholesterolemia in Primary Biliary Cirrhosis

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To the Editor: Hypercholesterolemia in patients with primary biliary cirrhosis is not consistently associated with preclinical carotid atherosclerosis.1 Although hypercholesterolemia has been documented worldwide as a major risk factor for illness and death from atherosclerotic disease, the mechanistic explanation for the absence of an increased risk of atherosclerotic disease among patients who have hypercholesterolemia and primary biliary cirrhosis remains largely unknown.1,2

We previously showed that patients with primary biliary cirrhosis and extreme hypercholesterolemia (total cholesterol level, >25.86 mmol per liter) had a substantial proportion of circulating lipoprotein X.3 Further in vitro studies revealed that lipoprotein X reduces the atherogenicity of . . . [Full Text of this Article]



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