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Correspondence
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Volume 357:1663 October 18, 2007 Number 16
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Management of an Inherited Predisposition to Breast Cancer

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by Robson, M.
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To the Editor: Robson and Offit (July 12 issue)1 report that among breast cancers detected by screening, 12% were seen on mammography but not on magnetic resonance imaging (MRI). The authors recommend that MRI be considered as a complement to mammography among women who are at increased risk for hereditary breast cancer. Among the "areas of uncertainty," they note the possibility that mammography may induce breast cancer in mutation carriers. The probability that mutation carriers have a high sensitivity to ionizing radiation may not be negligible,2,3 as was shown regarding the BRCA2 mutation in an animal model.4 This risk is . . . [Full Text of this Article]



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