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Previous Volume 357:1731-1743 October 25, 2007 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Celiac disease is a unique autoimmune disorder, unique because the environmental precipitant is known. The disorder was previously called celiac sprue, based on the Dutch word sprue, which was used to describe a disease similar to tropical sprue that is characterized by diarrhea, emaciation, aphthous stomatitis, and malabsorption.^1,2 Celiac disease is precipitated, in genetically predisposed persons, by the ingestion of gluten, the major storage protein of wheat and similar grains.³ Originally considered a rare malabsorption syndrome of childhood, celiac disease is now recognized as a common condition that may be diagnosed at any age and that affects many organ systems. . . . [Full Text of this Article]

Pathogenesis

The Role of Gluten

Mucosal Immune Responses

Genetic Factors

Environmental Factors

Epidemiology

Clinical Manifestations

Diagnosis

Serologic Testing

The Role of HLA-DQ2 and HLA-DQ8 Assessment

Biopsy and Histologic Assessment

Treatment

Assessment of Cases with a Poor Response to Therapy

Complications of Celiac Disease

Adenocarcinoma of the Small Intestine

Enteropathy-Associated T-Cell Lymphoma

Refractory Celiac Disease

Summary

Source Information

From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York (P.H.R.G.); and the Department of Gastroenterology, European Georges Pompidou Hospital, René Descartes Paris V University, Assistance Publique–Hôpitaux de Paris, INSERM U793, Paris (C.C.).

Address reprint requests to Dr. Green at the Department of Medicine, Columbia University College of Physicians and Surgeons, 180 Fort Washington Ave., Rm. 956, New York, NY 10032, or at pg11@columbia.edu.

Related Letters:

Celiac Disease
D'Angelo C., Mirijello A., Addolorato G., Levin D. M., Hadziselimovic F., Bürgin-Wolff A., Green P. H.R., Cellier C.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:747-749, Feb 14, 2008. Correspondence

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