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Previous Volume 357:1757-1759 October 25, 2007 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Before the licensure of the first inactivated hepatitis A vaccine in 1995, hepatitis A caused a substantial disease burden in the United States. Annual cases reported to the Centers for Disease Control and Prevention (CDC) numbered 25,000 to 30,000, but a more accurate estimate approached 300,000, since infection in young children often was subclinical and mild and self-limited disease in adults was underreported.¹ Infection rates were highest among children younger than 5 years of age, but only 30% of these children were symptomatic. Older children and adults had lower infection rates, but in approximately 70% of cases they were symptomatic. . . . [Full Text of this Article]

Source Information

From the Section of Infectious Diseases, the Department of Pediatrics, and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston.

This article (10.1056/NEJMe078189) was published at www.nejm.org on October 18, 2007.

This article has been cited by other articles:

• (2007). Postexposure Vaccination Will Prevent Hepatitis A. JWatch General 2007: 1-1 [Full Text]