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Correspondence
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Volume 357:1872-1873 November 1, 2007 Number 18
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More on Severe Cutaneous Reaction with Radiotherapy and Cetuximab

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To the Editor: In their letter to the editor, Budach et al. (Aug. 2 issue)1 report on two patients with squamous-cell carcinoma of the head and neck who had severe radiation dermatitis while receiving a combination of radiotherapy and cetuximab, a regimen found to be superior to radiotherapy alone in our proof-of-concept phase 3 trial.2 Severe radiation dermatitis can occur after irradiation alone, but grade 4 dermatitis is rarely observed. In reviewing the case histories of the patients, Budach et al. note that Patient 1 had previously received etoposide-based therapy and Patient 2 had previously received a full course of . . . [Full Text of this Article]


Related Letters:

Severe Cutaneous Reaction during Radiation Therapy with Concurrent Cetuximab
Budach W., Bölke E., Homey B.
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N Engl J Med 2007; 357:514-515, Aug 2, 2007. Correspondence

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