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Correspondence
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Volume 357:1874-1876 November 1, 2007 Number 18
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Pneumocystis Pneumonia Associated with Infliximab in Japan

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To the Editor: Infliximab, a monoclonal antibody against tumor necrosis factor {alpha} (TNF-{alpha}), is used in Japan for the treatment of patients with active rheumatoid arthritis that is resistant to methotrexate.1 Methotrexate is used only for patients who do not have a response to or cannot tolerate other disease-modifying antirheumatic drugs, such as sulfasalazine. Infliximab is not used as primary therapy for rheumatoid arthritis in Japan.

Strict postmarketing surveillance of infliximab and etanercept, a drug that blocks the action of TNF, revealed incidences of pneumocystis pneumonia in Japanese patients with rheumatoid arthritis that were higher (0.4% and 0.2%, respectively) than . . . [Full Text of this Article]



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