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Volume 357:1980-1982 November 8, 2007 Number 19
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Vitamin D Deficiency

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 by Holick, M. F.
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To the Editor: Holick's review of vitamin D deficiency (July 19 issue)1 is timely. We agree2 that the serum concentration of 25-hydroxyvitamin D should exceed 20 ng per milliliter to avoid bone problems. Data supporting much higher levels for bone or general health are weak and do not fulfill the criteria of evidence-based medicine.3,4,5 Requiring levels above 32 ng per milliliter implies that more than 80% of the European population and half of the world population are vitamin D–deficient. In Table 3 of his review, Holick recommends about 800 IU of vitamin D per day but also states that several . . . [Full Text of this Article]




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