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Correspondence
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Volume 357:1984-1985 November 8, 2007 Number 19
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JAK2 V617F Mutation in Unexplained Loss of First Pregnancy

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To the Editor: Unexplained pregnancy loss is a common health problem. Meta-analyses and reviews1 suggest that disorders promoting venous thrombosis, collectively termed "thrombophilias," contribute to the pathogenesis of fetal loss. The high variability among studies with respect to the associated risk between such disorders and unexplained pregnancy loss suggests the existence of underlying risk modifiers.

The V617F mutation of the Janus kinase 2 (JAK2) gene has been detected in most patients with polycythemia vera and in half of those with essential thrombocythemia.2 Pregnant women with polycythemia vera or essential thrombocythemia have reduced rates of live birth, with spontaneous . . . [Full Text of this Article]


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