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Editorial
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Volume 357:175-176 July 12, 2007 Number 2
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Genes, Cancer Risks, and Clinical Outcomes
Patricia Hartge, Sc.D.

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Learning whether a patient who has just been given a diagnosis of breast cancer also bears one of the cancer-causing mutations in the BRCA1 or BRCA2 genes may add little to the clinician's ability to select a therapy or predict the course of disease, once the grade and receptor status of the tumor and the age of the patient are taken into account. In this issue of the Journal, Rennert et al.1 support that line of reasoning with their study of Israeli women in whom breast cancer was diagnosed in 1987 or 1988. Reliable data on clinical outcomes in carriers . . . [Full Text of this Article]


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From the Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD.


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