Infection with hepatitis C virus (HCV) is a major worldwidecause of chronic liver disease, cirrhosis, and liver cancer,which together represent a chief global public health burden.Therapy has improved substantially since the introduction ofinterferon-alfa monotherapy in the late 1980s, when the responserate was less than 10%; now, combination therapy with peginterferonand ribavirin has a success rate of about 50%.1,2 Much likethe diverse outcomes of HCV infection, the response to treatmentvaries. Important factors associated with treatment responseinclude the race, age, sex, weight, and biochemical and histologiccharacteristics of patients. However, viral genotype and, . . . [Full Text of this Article]
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From the Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
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