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Studies of primary immunodeficiency diseases have had a critical role in expanding our understanding of the immune system and in the development of new treatments that have applications beyond immunodeficiency diseases. Robert A. Good, in the foreword to the first edition of this book, writes, "Analysis of each of the immune system diseases in its own way represents the molecular interpretation of an informative experiment of nature. In the aggregate, these analyses help us understand more deeply how man can exist free of infection while living in a veritable sea of microorganisms." The impact of these disorders on our understanding
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