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Volume 357:2087-2088 November 15, 2007 Number 20
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Prophylaxis vs. Episodic Treatment to Prevent Joint Disease in Severe Hemophilia

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by Manco-Johnson, M. J.
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To the Editor: The study of hemophilia prophylaxis by Manco-Johnson et al. (Aug. 9 issue)1 overestimates the annual cost of factor VIII treatment in young children. The authors state that the yearly cost "for a child weighing 50 kg could reach $300,000." Boys in the prophylaxis group received 6000 IU of factor VIII per kilogram of body weight per year by the age of 6 years, the study end point. Although the authors did not report the weights of the study participants, the median weight of a 6-year-old boy is 50 lb, or about 23 kg.2 On the basis of . . . [Full Text of this Article]



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