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Previous Volume 357:2199-2201 November 22, 2007 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hafler et al. of the International Multiple Sclerosis Genetics Consortium (Aug. 30 issue)¹ provide support for the previously tentative association between multiple sclerosis and alleles of the interleukin-2 receptor gene (IL2RA) and the interleukin-7 receptor gene (IL7RA). Although the evidence for a limited role of IL7RA in multiple sclerosis is compelling, as noted by Peltonen in the accompanying editorial,² the data are not definitive. Consistent replication of an effect for IL2RA and IL7RA in various populations would provide stronger evidence of causality.³ In addition, the large effect of the HLA class II region . . . [Full Text of this Article]

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